NBC: Research shows our bodies go through rapid changes in our 40s and our 60s
A new study came out on aging:
Research shows our bodies go through rapid changes in our 40s and our 60s
August 14, 2024
For many people, reaching their mid-40s may bring unpleasant signs the body isn’t working as well as it once did. Injuries seem to happen more frequently. Muscles may feel weaker.
A new study, published Wednesday in Nature Aging, shows what may be causing the physical decline. Researchers have found that molecules and microorganisms both inside and outside our bodies are going through dramatic changes, first at about age 44 and then again when we hit 60. Those alterations may be causing significant differences in cardiovascular health and immune function.
The findings come from Stanford scientists who analyzed blood and other biological samples of 108 volunteers ages 25 to 75, who continued to donate samples for several years.
“While it’s obvious that you’re aging throughout your entire life, there are two big periods where things really shift,” said the study’s senior author, Michael Snyder, a professor of genetics and director of the Center for Genomics and Personalized Medicine at Stanford Medicine. For example, “there’s a big shift in the metabolism of lipids when people are in their 40s and in the metabolism of carbohydrates when people are in their 60s.”
Lipids are fatty substances, including LDL, HDL and triglycerides, that perform a host of functions in the body, but they can be harmful if they build up in the blood. https://www.nbcnews.com/health/aging/research-shows-ages-metabolism-undergoes-massive-rapid-changes-rcna166367
Here is some of the actual report of the study in Nature Aging:
Abstract
Aging is a complex process associated with nearly all diseases. Understanding the molecular changes underlying aging and identifying therapeutic targets for aging-related diseases are crucial for increasing healthspan. Although many studies have explored linear changes during aging, the prevalence of aging-related diseases and mortality risk accelerates after specific time points, indicating the importance of studying nonlinear molecular changes. In this study, we performed comprehensive multi-omics profiling on a longitudinal human cohort of 108 participants, aged between 25 years and 75 years. The participants resided in California, United States, and were tracked for a median period of 1.7 years, with a maximum follow-up duration of 6.8 years. The analysis revealed consistent nonlinear patterns in molecular markers of aging, with substantial dysregulation occurring at two major periods occurring at approximately 44 years and 60 years of chronological age. Distinct molecules and functional pathways associated with these periods were also identified, such as immune regulation and carbohydrate metabolism that shifted during the 60-year transition and cardiovascular disease, lipid and alcohol metabolism changes at the 40-year transition. Overall, this research demonstrates that functions and risks of aging-related diseases change nonlinearly across the human lifespan and provides insights into the molecular and biological pathways involved in these changes. …
Discussion
Analyzing a longitudinal multi-omics dataset involving 108 participants, we successfully captured the dynamic and nonlinear molecular changes that occur during human aging. Our study’s strength lies in the comprehensive nature of the dataset, which includes multiple time point samples for each participant. This longitudinal design enhances the reliability and robustness of our findings compared to cross-sectional studies with only one time point sample for each participant. …
Lastly, our study’s molecular data are derived exclusively from blood samples, casting doubt on its direct relevance to specific tissues, such as the skin or muscles. We propose that blood gene expression variations might hint at overarching physiological alterations, potentially impacting the ECM in tissues, including skin and muscle. (Shen, X., Wang, C., Zhou, X. et al. Nonlinear dynamics of multi-omics profiles during human aging. Nat Aging (2024). https://doi.org/10.1038/s43587-024-00692-2) https://www.nature.com/articles/s43587-024-00692-2
Yes, we are all aging and apparently blood analysis points to a couple of times where aging effects accelerate.
Yet, we can have a better attitude about aging and take steps as we realize that this physical life is short.
Notice something that the Apostle Paul wrote”
16 Therefore we do not lose heart. Even though our outward man is perishing, yet the inward man is being renewed day by day. 17 For our light affliction, which is but for a moment, is working for us a far more exceeding and eternal weight of glory, 18 while we do not look at the things which are seen, but at the things which are not seen. For the things which are seen are temporary, but the things which are not seen are eternal. (2 Corinthians 4:16-18)
Hebert W. Armstrong, the late Pastor General of the old Worldwide Church of God, wrote the following related to attitudes about aging:
MILLIONS have been believing a myth that has brought on one of modern civilization’s greatest tragedies.
I saw a pitiful example of this one day in Miami. A few of my traveling team decided to take a drive over on Miami Beach. We crossed over near the southern end, then drove north to and through the luxury hotel area. But driving up from the southern end we passed first through a district of economy-class retirement hotels.
As we drove slowly by, our attention was arrested by the sight of many retired “elderly” — probably between the ages of 60 and 70 — sitting idly on front verandas passing away the time. It was the despondent, hopeless, beaten look on their faces that caught our attention and filled us with dismay. Plainly, they had nothing to look forward to. There was just a tired, uninterested, hopeless stare on their faces. They were just eking out an existence until finally death would deliver them from hopeless monotony.
I had to wonder: WHY should people believe in a myth that cheats millions out of one of the happiest times of life? WHY should the MILLIONS believe a myth that makes them old before their time and robs them of usefulness, vigor, sparkling interest in life, and real accomplishment?
I remember when I was a boy still growing up. My two grandfathers were dead, but my grandmothers, one in her late 50s, the other in her early 60s, were still living. Not that my ancestors died young. I remember, between ages 3 and 5, a great grandfather in his 90s and a great uncle, also in his 90s. My mother lived to age 95 1/2, and she had brothers and sisters who lived into their late 80s and 90s.
But my grandmothers, after about age 50 or 55, had changed their attire to dress like “old folks.” It has seemed to me that it must have become custom for people to think they are “growing old.” I have noticed that many young men, reaching somewhere around 25, begin to cultivate a changed personality, put on a facial expression, and adopt a manner of speech of one “more MATURE.” As they reach the later 40s and turn 50, they seem to feel they must talk, look, and act like they suppose the “middle-aged” ought to appear. And by or before 60, they seem to feel they have now become “old.” They appear to feel their usefulness is now over, and they must “retire.”
This feeling is so universal that many corporations have retirement programs timed to age 60 or 65.
Somehow, I never could quite understand that type of outlook on life. I have never reached “middle age,” at least not consciously — not in my mind and manner of thinking and acting. After age 83, I have enjoyed joking about being “37, going on 36.” I have simply been TOO BUSY to think of “growing old” or ever “retiring.”
One of our employees came to me at age 55. He wanted to retire. True, he had been on our payroll for some 25 or 30 years. He had been divorced and had married a widow who had a camper. She had a small income.
“We can travel very cheaply,” he said, “and I want to get to travel and see some of the United States before I have to meet my Maker,” he said. He had already “grown old” — in his mind. Well, “as he thinketh in his heart, so is he,” said Solomon. (Armstrong HW. THE WESTERN WORLD’S GROWING TRAGEDY – GROWING OLD BEFORE OUR TIME. Plain Truth, December 1976)
Herbert W. Armstrong worked until he died at age 93 1/2. In my upper 60s, I also continue to work. He and I both dedicated our lives to strive to do and support the end-time work of God.
The Book of Ecclesiastes discusses being young and old and that even the young should remember God from the New Living Translation:
1 Don’t let the excitement of youth cause you to forget your Creator. Honor him in your youth before you grow old and say, “Life is not pleasant anymore.” 2 Remember him before the light of the sun, moon, and stars is dim to your old eyes, and rain clouds continually darken your sky. 3 Remember him before your legs—the guards of your house—start to tremble; and before your shoulders—the strong men—stoop. Remember him before your teeth—your few remaining servants—stop grinding; and before your eyes—the women looking through the windows—see dimly.
4 Remember him before the door to life’s opportunities is closed and the sound of work fades. Now you rise at the first chirping of the birds, but then all their sounds will grow faint.
5 Remember him before you become fearful of falling and worry about danger in the streets; before your hair turns white like an almond tree in bloom, and you drag along without energy like a dying grasshopper, and the caperberry no longer inspires sexual desire. Remember him before you near the grave, your everlasting home, when the mourners will weep at your funeral.
6 Yes, remember your Creator now while you are young, before the silver cord of life snaps and the golden bowl is broken. Don’t wait until the water jar is smashed at the spring and the pulley is broken at the well. 7 For then the dust will return to the earth, and the spirit will return to God who gave it. (Ecclesiastes 12:1-7)
Yes, we should change and better serve God as soon as we can. And that even includes those who are elderly, as well as the young.
Jeremiah was inspired to write:
25 The Lord is good to those who wait for Him,
To the soul who seeks Him.
26 It is good that one should hope and wait quietly
For the salvation of the Lord.
27 It is good for a man to bear
The yoke in his youth. (Lamentations 3:25-27)
Yes, it is better to start as young as you can to serve God.
The Psalmist wrote:
2 Bless the Lord, O my soul, And forget not all His benefits: 3 Who forgives all your iniquities, Who heals all your diseases, 4 Who redeems your life from destruction, Who crowns you with lovingkindness and tender mercies, 5 Who satisfies your mouth with good things, So that your youth is renewed like the eagle’s.
Notice also the following:
25 I have been young, and now am old;
Yet I have not seen the righteous forsaken (Psalms 37:25)
Yes, all will either die first or get old. If you do not wish to ever be forsaken, live God’s righteous ways.
Remember, too, the Bible teaches:
172 … all Your commandments are righteousness. (Psalms 119:172)
And yes, you are better off keeping God’s commandments as soon as you can.
The Book of Psalms also teach:
4 “Lord, make me to know my end,
And what is the measure of my days,
That I may know how frail I am. (Psalms 39:4)9 For all our days have passed away in Your wrath;
We finish our years like a sigh.
10 The days of our lives are seventy years;
And if by reason of strength they are eighty years,
Yet their boast is only labor and sorrow;
For it is soon cut off, and we fly away.
11 Who knows the power of Your anger?
For as the fear of You, so is Your wrath.
12 So teach us to number our days,
That we may gain a heart of wisdom. (Psalms 90:9-12)
Realizing that we will die should motivate all of us to consider that we need our Saviour for salvation.
16 For God so loved the world that He gave His only begotten Son, that whoever believes in Him should not perish but have everlasting life. 17 For God did not send His Son into the world to condemn the world, but that the world through Him might be saved. (John 3:16)
9 … He became the author of eternal salvation to all who obey Him, (Hebrews 5:9)
Yes, we all get older everyday.
Here are some items that can possibly assist your health as you age:
Christian Health Matters Should Christians be concerned about their health? Does the Bible give any food and health guidelines? Here are links to three related sermons: Let’s Talk About Food, Evil is Affecting the Food Supply, and Let’s Talk About Health.
Should Christians Smoke (or Chew) Tobacco or Marijuana? Is smoking a sin? What does the Bible teach? What have COG leaders written? Can smokers change? What about marijuana? Here is a link to a related video: Should You Smoke? Would You Like Help to Quit?
Marijuana: Should a Christian Get High? There is increasing acceptance of the use of marijuana. How should Christians view this? Here is a related video titled How Should a Christian View Marijuana?
Alcohol: Blessing or Curse? This is an article from the old Good News magazine that attempts to answer this question.
Binge Drinking, Health, and the Bible Many college students and others overindulge in alcohol. Are there health risks? What does the Bible teach? A related video is also available: Binge Drinking and the Bible.
Obesity, processed foods, health risks, and the Bible Does the Bible warn about the consequences of being obese? Is overeating dangerous? Is gluttony condemned? What diseases are associated with eating too much refined foods? A related video would be Eating Right, Eating Too Much, and Prophecy.
Should Christians Exercise? What does the Bible teach? What are some of the benefits and risks of exercise? Here is a link to a related video: The Plain Truth About Exercise.
Ten Simple Rules that Lead to Health Herbert Armstrong gives his opinions on this.
But more than the physical, we realize that this life is temporal.
Therefore, it should be an urgent imperative for us to fully live God’s way and obey Him.
God does have a plan for you — and the more you embrace it, the better your eternity will be (see also the free online book: The MYSTERY of GOD’s PLAN: Why Did God Create Anything? Why Did God Make You?).
And yes, for all of us, we need to change and improve our focus on God, His ways, His end-time work and His coming Kingdom
We related to aging, we also have the following video:
Let’s Talk About Aging
Could you have the wrong attitude about aging and the elderly? Should your goal to be to retire and cease being productive? What did Herbert W. Armstrong say about it? What does the Bible say about aging? Is it better to listen to God when you are in your youth? What about later? Since physical life is temporary, should that motivate us to better obey God? What are some things we can do physically in order to be healthier? What about avoiding things like smoking, too much alcohol, and obesity? What about spiritual things such as prayer, Bible study, paying attention to church services, and fasting? Are there benefits responding to God sooner than later? Who is Jesus the author of ETERNAL SALVATION for? Steve Dupuie and Dr. Thiel go over these matters.
Here is a link to our video: Let’s Talk About Aging.
Several items of possibly related interest include:
The MYSTERY of GOD’s PLAN: Why Did God Create Anything? Why Did God Make You? This free online book helps answers some of the biggest questions that human have, including the biblical meaning of life. Here is a link to three related sermons: Mysteries of God’s Plan, Mysteries of Truth, Sin, Rest, Suffering, and God’s Plan, Mystery of Race, and The Mystery of YOU. Here is a link to two videos in Spanish: El Misterio del Plan de Dios and El Misterio de Satanás, el Misterio de la Verdad, el Misterio del Reposo.
Christian Health Matters Should Christians be concerned about their health? Does the Bible give any food and health guidelines? Here are links to three related sermons: Let’s Talk About Food, Evil is Affecting the Food Supply, and Let’s Talk About Health.
Should Christians Smoke (or Chew) Tobacco or Marijuana? Is smoking a sin? What does the Bible teach? What have COG leaders written? Can smokers change? What about marijuana? Here is a link to a related video: Should You Smoke? Would You Like Help to Quit?
Marijuana: Should a Christian Get High? There is increasing acceptance of the use of marijuana. How should Christians view this? Here is a related video titled How Should a Christian View Marijuana?
Alcohol: Blessing or Curse? This is an article from the old Good News magazine that attempts to answer this question.
Binge Drinking, Health, and the Bible Many college students and others overindulge in alcohol. Are there health risks? What does the Bible teach? A related video is also available: Binge Drinking and the Bible.
Obesity, processed foods, health risks, and the Bible Does the Bible warn about the consequences of being obese? Is overeating dangerous? Is gluttony condemned? What diseases are associated with eating too much refined foods? A related video would be Eating Right, Eating Too Much, and Prophecy.
Should Christians Exercise? What does the Bible teach? What are some of the benefits and risks of exercise? Here is a link to a related video: The Plain Truth About Exercise.
The Gospel of the Kingdom of God This free online pdf booklet has answers many questions people have about the Gospel of the Kingdom of God and explains why it is the solution to the issues the world is facing. It is available inover 1,000 languages at ccog.org. Here are links to four kingdom-related sermons: The Fantastic Gospel of the Kingdom of God!, The World’s False Gospel, The Gospel of the Kingdom: From the New and Old Testaments, and The Kingdom of God is the Solution.
Who Was Herbert W. Armstrong? How is He Viewed Today? Includes quotes from the 1973 edition of The Autobiography of Herbert W. Armstrong and explains how he is and should be viewed today.
What is Armstrongism? Did Herbert W. Armstrong raise a new faith or promote the original Christian faith? Here is a link to a related video: What is Armstrongism? Are Some Dismissive of Original Christianity?
Herbert W. Armstrong, the Philadelphia Church, & the Mantle Herbert Armstrong claims God had him raise the Philadelphia up. Are there reasons to believe that the Philadelphia mantle in now within the CCOG? Here is a link to a related sermon: Herbert W. Armstrong and the Philadelphia Mantle.
6. The Philadelphia Church Era was predominant circa 1933 A.D. to 1986 A.D. The old Radio Church of God and old Worldwide Church of God, now the remnant of that era is basically the most faithful in the Church of God, like who hold to the beliefs and practices of the Continuing Church of God.
7. The Laodicean Church Era has been predominant circa 1986 A.D. to present. The Laodiceans are non-Philadelphians who mainly descended from the old WCG or its offshoots. They do not properly understand the work or biblical prophecies and will face the Great Tribulation if they do not repent. One video of related interest is 50+ Laodicean Prophetic Errors. See also Do You Hold to Any of These Laodicean Prophetic Errors?
Is God Calling You? This booklet discusses topics including calling, election, and selection. If God is calling you, how will you respond? Here is are links to related sermons: Christian Election: Is God Calling YOU? and Predestination and Your Selection; here is a message in Spanish: Me Está Llamando Dios Hoy? A short animation is also available: Is God Calling You?
Christian Repentance Do you know what repentance is? Is it really necessary for salvation? Two related sermons about this are also available: Real Repentance and Real Christian Repentance.
About Baptism Should you be baptized? Could baptism be necessary for salvation? Who should baptize and how should it be done? Here is a link to a related sermon: Let’s Talk About Baptism and Baptism, Infants, Fire, & the Second Death.
Christians: Ambassadors for the Kingdom of God, Biblical instructions on living as a Christian This is a scripture-filled booklet for those wishing to live as a real Christian. A related sermon is also available: Christians are Ambassadors for the Kingdom of God. Here is a video in Spanish: ¿Qué es un verdadero cristiano?
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