Semaglutide may help some with type 1 diabetes and obesity, but there are issues

The branded version of semaglutide, called #Ozempic, has surged in popularity—and notoriety—for its off-label use as a weight-loss medication. Here’s what to know about this in-demand drug. https://t.co/CN3yCtdwTy pic.twitter.com/LiPHEfnWvB

— JAMA (@JAMA_current) May 15, 2023

COGwriter

There have been reports that the drug semaglutide may help some with type 1 diabetes as well as obesity. Here is part of one report:

September 6, 2023

Results of a new study from the State University of New York at Buffalo (University at Buffalo) suggest use of semaglutide in people with newly diagnosed type 1 diabetes eliminated the need for mealtime insulin doses among the entire study cohort and allowed 70% to eliminate basal insulin use within 6 months, with the mean HbA1c decreasing from 11.7% at baseline to 5.9% at 6 months and 5.7% at 12 months.¹

“We were definitely surprised by our findings and also quite excited. If these findings are borne out in larger studies over extended follow-up periods, it could possibly be the most dramatic change in treating Type 1 diabetes since the discovery of insulin in 1921,” said lead investigator Paresh Dandona, MD, PhD, former chief of the Division of Endocrinology in the Jacobs School of Medicine and Biomedical Sciences at the University at Buffalo.²

The GLP-1 receptor agonist class, particularly semaglutide, has been in the spotlight of the medical community in recent years as revelations surrounding its potential in chronic weight management have come to light. During this time, the popularity of semaglutide has grown to the point where demand for use as a weight loss agent, both on and off-label, has resulted in the agent’s listing on the FDA Drug Shortages database.³ https://www.hcplive.com/view/semaglutide-could-eliminate-need-for-insulin-in-type-1-diabetes

But there are concerns. Here is a comment from a medical doctor at the JAMA’s (Journal of the American Medical Association) website:

Gauranga Dhar, MD | Private Practice

No doubt semaglutide, a novel GLP-1 agonist, is associated with a number of favorable effects including cardiorenal benefits. But its use also should be cautious.

Since it is used to manage type 2 diabetes and obesity, theoretically semaglutide should be used lifelong.

I am a practicing physician who took the drug and could not continue it more than a few months maximum because of number of gastrointestinal adverse effects.

Medullary thyroid carcinoma (MTC) is one of the adverse effects of semaglutide, and that’s why before starting this molecule, a physician should think twice and take a detailed family history. 05/01/23 https://jamanetwork.com/journals/jama/article-abstract/2804462?utm_source=twitter&utm_medium=social_jama&utm_term=9899181571&utm_campaign=article_alert&linkId=213705703

Additionally, notice the following:

‘Miracle’ Weight Loss Drug Manufacturers About to Get Sued Into Oblivion?

September 6, 2023

Originally published via American Thinker:

“Give me convenience of give me death.”
-Dead Kennedys

I get a veritable avalanche of breathless complaints from (probably obese) individuals when I write about semaglutide (marketed as Wegovy and Ozempic in the United States). Their objections tend to go along the lines of: “but muh pharma. How else am I supposed to lose weight?”

The obeses call me a fascist – exercise and eating right now being apparently “right-wing.” They say I’m unempathetic and don’t understand their plight for even suggesting they don’t turn to expensive pharmaceutical products as their first-resort solution to their problems. …

Now at least one American law firm is taking up the cases of individuals injured by these aggressively marketed “miracle” weight loss drugs. This is the first lawsuit I’m aware of, but it almost certainly won’t be the last given the side effect profile of semaglutide.

Via CBS News:

“A personal injury law firm has filed a lawsuit against Novo Nordisk and Eli Lilly and Co., the manufacturers of Ozempic and Mounjaro, over claims that the diabetes drugs, which are popular for aiding weight loss, can cause gastroparesis, a paralysis of the stomach.

Paul Pennock and Jonathan Sedgh, the attorneys heading up the lawsuit from the firm Morgan & Morgan, announced the filing at a news conference Wednesday, saying the basis of the suit is “a failure to warn.”

“It is our opinion that these drugs are causing these problems. We think that the evidence is sufficient for us to be able to prove it or we would not have filed the case, and we intend to file many more in the coming days and weeks,” Pennock said during the Zoom conference, noting the first case filed involves a 44-year-old woman from Louisiana who has taken both drugs, Ozempic first and then Mounjaro, at the discretion of her doctor.

“Her problems have been so severe that she’s been to the emergency room multiple times, including last weekend. She’s actually even thrown up so violently that she’s lost teeth,” he said of the plaintiff, who is seeking financial compensation, but has not yet been officially diagnosed with gastroparesis.

Pennock says his firm is investigating 400 other inquiries from clients across 45 states.”

What’s a little projectile vomiting so violent that it knocks teeth out when fast weight loss is on the line? We’ll see how a jury comes down on the cost-benefit analysis if this ever goes to trial (it’ll probably be settled for PR purposes).

There are no one-shot, simple solutions for complex health issues, despite what sleazy drug pushers might claim. https://www.zerohedge.com/news/2023-09-06/miracle-weight-loss-drug-manufacturers-about-get-sued-oblivion

Over the past six or so decades, there have been numerous drugs that supposedly would combat obesity.

And while some have been helped by them, pharmaceutical weight-loss medications also tend to have side effects which have either eliminated or at least limited their use.

In time, more and more negative “side effects” of previous weight-loss drugs have tended to come out. That seems likely to happen with semaglutide–but we will see.

That said, consider the following scripture:

11 … In vain you will use many medicines; You shall not be cured. (Jeremiah 46:11)

Weigh is a multi-factorial problem. Thinking one drug or a combination of drugs will solve it is not realistic, nor borne out by statistics over the past several decades.

Despite various pharmaceutical approaches, obesity is increasing in many places:

More Than Half the World Will Be Overweight or Obese by 2035

March 2, 2023

More than half of the world’s population will be overweight or obese by 2035 without significant action, according to a new report.

The World Obesity Federation’s 2023 atlas predicts that 51% of the world, or more than 4 billion people, will be obese or overweight within the next 12 years.

Rates of obesity are rising particularly quickly among children and in lower income countries, the report found.

Describing the data as a “clear warning,” Louise Baur, president of the World Obesity Federation, said that policymakers needed to act now to prevent the situation worsening.

“It is particularly worrying to see obesity rates rising fastest among children and adolescents,” she said in a statement.

“Governments and policymakers around the world need to do all they can to avoid passing health, social and economic costs on to the younger generation.”

The report found that childhood obesity could more than double from 2020 levels, to 208 million boys and 175 million girls by 2035.

The cost to society is significant as a result of the health conditions linked to being overweight, the federation said: more than $4 trillion annually by 2035, or 3% of global GDP. https://www.newsmax.com/health/health-news/obesity-overweight-childhood/2023/03/02/id/1110747/

While I do NOT now believe that most of the world will be highly overweight in 2035, as “this present evil age” (Galatians 1:4) may be over by then (see also Does God Have a 6,000 Year Plan? What Year Does the 6,000 Years End?), we certainly are seeing more and more overweight people.

Having more highly overweight people is consistent, however, with the following prophecy for the last days:

1 But know this, that in the last days perilous times will come: 2 For men will be lovers of themselves, lovers of money, boasters, proud, blasphemers, disobedient to parents, unthankful, unholy, 3 unloving, unforgiving, slanderers, without self-control, brutal, despisers of good, 4 traitors, headstrong, haughty, lovers of pleasure rather than lovers of God, 5 having a form of godliness but denying its power. And from such people turn away! (2 Timothy 3:1-6)

Lack of self-control, while not the only factor, is a factor in obesity.

Notice also the following related to obesity:

The Societal Cost of Obesity

According to researchers at Ball State University in Indiana, obesity is on the rise. Estimates based on their early research show that by 2030, in the absence of any intervening actions, a third of all children between the ages of six and eleven will be considered obese or overweight.

No doubt that is a shocking statistic. …

To measure whether or not you are overweight or obese, you must account for your Body Mass Index or BMI.

For adults, BMI consists of a person’s weight divided by their height squared. …

For children, BMI is calculated using the same formula but is interpreted using the child’s age and sex. Those results are then measured amongst a percentile. This method accounts for the difference in adolescent development for those between the ages of 2 and 19.

Health risks can occur in any individual, no matter their lifestyle or level of fitness. But for those who are obese, there is a far more heightened risk of experiencing serious health conditions. The list of potential health problems and complications is extensive and includes:

Type 2 diabetes

High blood pressure (Hypertension)

Risk for stroke

Sleep apnea

Difficulty breathing

Coronary heart disease

Problems regulating healthy cholesterol levels (high LDL, low HDL, high levels of triglycerides

Certain types of cancers including breast, colon, endometrial, gallbladder, kidney, liver, ovarian, or pancreatic

Gallbladder disease

Osteoarthritis (deterioration of bone and cartilage in joints)

Greater risk for mental illness including anxiety, clinical depression, and other psychiatric disorders

Reduced quality of life (excessive pain, limited mobility, problems performing everyday tasks, such as standing, walking, or using the restroom)

In practically all instances, obesity also enhances the risk of premature death. …

Based on several estimates, the US has spent anywhere from $150 billion to upwards of $190 billion each year on obesity-related costs. Some put that range even higher. This includes diagnosis and treatment, as well as prevention-related costs.

By 2030 – a little over a decade away – those numbers could increase by as much as $66 billion a year.

Those figures, though, only take into account direct costs. They do not account for lost work (either in lost employee wages or lost employer productivity), insurance costs, or lower overall wages. According to some of the most prevalent reports, these secondary financial consequences are an even larger burden that the direct medical costs of obesity.

At its most extreme, obesity may prove to be one of humankind’s worst maladies. https://www.mbahealthcaremanagement.org/topics/the-societal-cost-of-obesity/ accessed 08/24/19

The USA is already massively in debt and future increases in health care costs and decreased productivity can be part of ‘the straw that will break the camel’s back’ metaphorically.

The Bible opposes obesity.

Here is what Moses and Jeremiah were inspired to write about obesity thousands of years ago:

15 You grew fat, you grew thick,
You are obese!
Then he forsook God who made him,
And scornfully esteemed the Rock of his salvation.
16 They provoked Him to jealousy with foreign gods;
With abominations they provoked Him to anger. (Deuteronomy 32:15-16)

11 “Because you were glad, because you rejoiced,
You destroyers of My heritage,
Because you have grown fat like a heifer threshing grain,
And you bellow like bulls,
12 Your mother shall be deeply ashamed;
She who bore you shall be ashamed.
Behold, the least of the nations shall be a wilderness,
A dry land and a desert. (Jeremiah 50:11-12)

The idea that one should not be obese is not a new one.

Furthermore, the Bible warns about gluttony as well as eating things that are not really food:

20 Do not mix with winebibbers, Or with gluttonous eaters of meat; 21 For the drunkard and the glutton will come to poverty (Proverbs 23:20-21)

2 Why do you spend money for what is not bread,
And your wages for what does not satisfy?
Listen carefully to Me, and eat what is good (Isaiah 55:2).

Eat what is good.

Do not overeat. That is easy to say, but often difficult to do.

Most in Westernized areas consume too much overly-processed convenience foods, synthetic nutrients, chemical additives, and refined grains (see also UK’s health problems and ultra-processed ‘foods’ and Most calories for Americans come from ultra-processed ‘foods’).

People should try to eat real, not artificial, foods. Soda consumption should be almost non-existent, essentially a very rare treat.

And while they do not like to believe this, almost all obese people also need to eat less.

Many years ag0, the Continuing Church of God put out a video about concerns about eating to much on our YouTube channel called Bible New Prophecy.

Eating Right, Eating Too Much, and Prophecy

Are there disadvantages to being overweight? Is junk food really bad for you? Does the Bible discuss overeating and/or obesity? Is overeating having an effect on the US military? What are the ramifications of personal and national health for overeating? What should you eat?

Here is a link to our video: Eating Right, Eating Too Much, and Prophecy.

We more recently put out the following video:

1:07:48

Evil is Affecting the Food Supply

God gave humans food and said what He made was good. What about unclean animals? What about genetically-modified organisms (GMOs)? What about ‘bioengineered foods’? What about lab meat? What about human-cloned salami? What about ‘Piggy Sooy’? Are Christians supposed to eat what is good according to Isaiah 55:2? What should we eat? What should Christians avoid eating? Dr. Thiel addresses these matters and more.

Here is a link to the following: Evil is Affecting the Food Supply.

That said, losing weight can be very, very difficult. But real Christians should believe the following:

13 I can do all things through Christ who strengthens me. (Philippians 4:13)

With prayer and proper determination, breaking away from being obese can happen.

The Bible teaches:

5 Trust in the Lord with all your heart,
And lean not on your own understanding;
6 In all your ways acknowledge Him,
And He shall direct your paths.

7 Do not be wise in your own eyes;
Fear the Lord and depart from evil.
8 It will be health to your flesh,
And strength to your bones. (Proverbs 3:5-8)

32 Do not fear, little flock, for it is your Father’s good pleasure to give you the kingdom. (Luke 12:32)

Do not let fear stop you from moving ahead.

Take proper action (cf. Galatians 6:9-10; Revelation 3:7-13; Zephaniah 2:1-3).

Interested in a spiritual ‘five second’ rule?

Tell yourself and pray:

I will act on the truth and not put it off because I do not feel like it. Jesus help me.

Most people can quietly pray that in 5 or so seconds.

And physically if it will help, you can count backwards from five or use some other technique to motivate you to do what is right–including with your diet. But then pray for God’s assistance.

We also have a related video:

16:02

‘How to Change Your Life in 5 Seconds’

Inc. magazine posted an article online titled ‘How to Change Your Life in 5 Seconds.’ In it, Mel Robbins explains how she developed a technique to be more productive. She observed that 95% of decisions are based on emotion instead of logic, and how and why adding a five-second countdown helped her life. She mentions that fear, anger, and other factors often interfere with our ability to be better people. In this video, Dr. Thiel quotes a lot from that article, including some of the science behind the technique. He also quotes Jesus as well as many passages from the Bible. He also teaches a 5 second statement to say and pray to use as a five second spiritual statement to help Christians change.

Here is a link to the video: ‘How to Change Your Life in 5 Seconds’.

Of course, some things take longer than 5 seconds. But asking Jesus to help you not overeat is something everyone can do.

While it may not help your weight much, exercising is good for you and your innate immune system. Related to exercise, the Continuing Church of God (CCOG) put out the following video on our Bible News Prophecy YouTube channel:

17:27

The Plain Truth About Exercise

A 2019 report shows that Americans are becoming sedentary. Since it is a physical thing, should Christians be concerned about exercise? Could not exercising possibly be a sin? What did the ‘Plain Truth’ magazine report about exercise? What is the US CDC reporting about exercise? Can exercise help prevent diabetes, heart disease, and obesity? Can exercise help sleep, endurance, and aging? Are there scriptures about exercise and health? What about laziness? What are some of the risks and benefits of exercise? Dr. Thiel addresses these subjects and more.

Here is a link to our video: The Plain Truth About Exercise.

That being said, the US is prophesied to lose militarily in the relatively near future (cf. Daniel 11:39).

It could be that health issues, including obesity, will end up being partial factors for the defeat.

Now, related to food, we put out the following video:

1:11:59

Let’s Talk About Food

The Bible says to eat what is good. Does the Bible give any information on what to eat and not eat? What happened in the Garden of Eden? What about Noah? What are clean and unclean animals? Did early Christians avoid biblically-unclean animals? What are some of the health risks associated with eating pork, shellfish, and bats? Are pigs associated with the flu? Could bats have been involved related to the corona virus pandemic? Should humans consume blood? What are enzymes? Can raw foods aid in health? Is the typical US diet deadly? What about processed foods? Is eating refined sugar necessary? How were vitamins discovered? What about United States Pharmacopeia (USP) vs. food vitamins? Are most mineral supplements composed of processed rocks? What about genetically-modified organisms (GMOs)? What about sodas and other beverages? Dr. Thiel addresses these matters and more.

Here is a link to the sermon: Let’s Talk About Food.

Related to Christian health, we put out the following video:

1:20:07

Let’s Talk About Health

While the Bible focuses on the spiritual, it also has information on the physical. Does God want Christians to be in good health? What about the use of medications? What about supporting the immune system? Should Christians smoke or use marijuana? What about alcohol? Are there any risks from electromagnetic fields (EMF) or radiofrequency (RF) radiation? What about cellular telephones and 5G? Are Christians supposed to exercise? Can exercise improve brain function and reduce the risk of cognitive decline? Are we to avoid laziness and minimize junk foods? Does the Bible condemn obesity and gluttony? What can help with weight loss? Can you eat too much honey according to scripture? Are there health benefits to fasting? Should we rest on the Sabbath, honor our parents, avoid sexual immorality, and keep God’s commandments? What about prayer and health? Dr. Thiel discusses these matters and concludes by summarizing 26 matters for Christian health.